New small ^99mTc-labeled peptides for HER2 receptor imaging

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• 作者：Hamideh Sabahnoo^a ; ^c ; Zohreh Noaparast^a ; ^c ; Seyed Mohammad Abedi^b ; Seyed Jalal Hosseinimehr^a ; ^c ; ^{sjhosseinim@yahoo.com} ; ^{sjhosseinim@mazums.ac.ir}
• 关键词：LTVSPWY ; 99mTc ; HER2 receptor ; Cysteine-based ligand ; Tumor uptake ; Peptide
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：1012-1024
• 全文大小：2048 K
• 卷排序：127

文摘

New small peptides were introduced as selective anti-HER2 target. Two peptide-based chelators CGGG and CSSS were used for labeling of heptapeptide LTVSPWY peptide with 99mTc. High labeling yield and specific binding to HER2 with nanomolar affinity. The polarity of the amino acids in the peptide based chelators affected on pharmacokinetics of these peptides. The best pharmacokinetic and as well as the higher tumor uptake was obtained for the 99mTc-CSSS-LTVSPWY peptide.