Tailoring Renal Clearance and Tumor Targeting of Ultrasmall Metal Nanoparticles with Particle Density
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- 作者：Dr. Shaoheng Tang ; Chuanqi Peng ; Jing Xu ; Bujie Du ; Qingxiao Wang ; Rodrigo D. Vinluan III ; Dr. Mengxiao Yu ; Prof. Dr. Moon J. Kim and Prof. Dr. Jie Zheng
- 刊名：Angewandte Chemie International Edition
- 出版年：2016
- 出版时间：December 23, 2016
- 年：2016
- 卷：55
- 期：52
- 页码：16039-16043
- 全文大小：3014K
- ISSN：1521-3773
文摘
Identifying key factors that govern the in vivo behavior of nanomaterials is critical to the clinical translation of nanomedicines. Overshadowed by size-, shape-, and surface-chemistry effects, the impact of the particle core density on clearance and tumor targeting of inorganic nanoparticles (NPs) remains largely unknown. By utilizing a class of ultrasmall metal NPs with the same size and surface chemistry but different densities, we found that the renal-clearance efficiency exponentially increased in the early elimination phase while passive tumor targeting linearly decreased with a decrease in particle density. Moreover, lower-density NPs are more easily distributed in the body and have shorter retention times in highly permeable organs than higher-density NPs. The density-dependent in vivo behavior of metal NPs likely results from their distinct margination in laminar blood flow, which opens up a new path for precise control of nanomedicines in vivo.