Peripheral inflammation related to lower fMRI activation during a working memory task and resting functional connectivity among older adults: a preliminary study
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- 作者：Sheena I. Dev ; Raeanne C. Moore ; Benchawanna Soontornniyomkij ; Cristian L. Achim ; Dilip V. Jeste and Lisa T. Eyler
- 刊名：International Journal of Geriatric Psychiatry
- 出版年：2017
- 出版时间：March 2017
- 年：2017
- 卷：32
- 期：3
- 页码：341-349
- 全文大小：217K
- ISSN：1099-1166
文摘
Peripheral inflammation has been associated with adverse effects on cognition and brain structure in late life, a process called ‘inflammaging.’ Identifying biomarkers of preclinical cognitive decline is critical in the development of preventative therapies, and peripheral inflammation may be able to serve as an indicator of cognitive decline. However, little is known regarding the relationship between peripheral inflammation and brain structure and function among older adults.