Cover Picture: Eur. J. Immunol. 3'16

详细信息    查看全文

• 刊名：European Journal of Immunology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：46
• 期：3
• 全文大小：351K
• ISSN：1521-4141

文摘

Our cover features a collage of immunofluorescence stainings of primary microglia with NF-κB p65 (green) and DAPI (blue). The image is taken from Shi et al. (pp. 665–676), where the authors studied the anti-inflammatory effect of natural chemical compound gx-50 from Chinese black pepper (Zanthoxylum bungeanum) in primary rat microglia and a mouse model of Alzheimer's disease (AD). Gx-50 reduced the release of pro-inflammatory mediators induced by amyloid ß and inhibited TLR4-mediated NF-κB/MAPK signaling cascade. This study suggests that gx-50 should be further analyzed as potential candidate drug for the treatment of AD.