Nickel-Catalyzed Facile [2+2+2] Cyclotrimerization of Unactivated Internal Alkynes to Polysubstituted Benzenes
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- 作者：Dr. Fei Xue ; Ying Kai Loh ; Dr. Xiaolu Song ; Wei Jie Teo ; J. Y. Darrence Chua ; Dr. Jin Zhao and Prof. Dr. T. S. Andy Hor
- 刊名：Chemistry – An Asian Journal
- 出版年：2017
- 出版时间：January 3, 2017
- 年：2017
- 卷：12
- 期：1
- 页码：168-173
- 全文大小：493K
- ISSN：1861-471X
文摘
A catalytic [2+2+2] cyclotrimerization of unactivated internal alkynes providing cyclotrimerization products in excellent yields with high regioselectivity is described. The transformation is accomplished by using a simple catalytic mixture comprising Ni(acac)2, an imidazolium salt and a Grignard reagent at room temperature or 60 °C for 20 min or 1 h.