Phytochemical composition, cellular antioxidant capacity and antiproliferative activity in mango (Mangifera indica L.) pulp and peel

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• 作者：Arshad Mehmood Abbasi ; Fengyun Liu ; Xinbo Guo ; Xiong Fu ; Tong Li and Rui Hai Liu
• 刊名：International Journal of Food Science & Technology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：52
• 期：3
• 页码：817-826
• 全文大小：463K
• ISSN：1365-2621

文摘

Cellular antioxidant activity (CAA) and inhibition of hepato-cellular carcinoma (HepG2) proliferation were evaluated for the first time in the pulp and peel of mango cultivars. Comparatively, peel had high flavonoids and tocopherols content and showed significant antioxidant activity. Among all the studied cultivars, the Xiao Tainong peel was predominant with highest fistein, mangiferin and alpha-tocopherol content and significant cellular antioxidant activity value 2986 ± 380 μmol QE/100 g FW. The HepG2 cells antiproliferation was maximum in the peel of Da Tainong and pulp of Aozhou with lowest EC₅₀ values, 2.35 ± 0.65 (peel) and 185.4 ± 10.9 (pulp) mg mL⁻¹, in a dose-dependent manner. Negative associations of flavonoids and tocopherol compounds with CAA and antiproliferative activity in mango confirmed synergistic, additive or antagonistic actions of phytochemicals. The current study suggests that mango peel could be used as a value added ingredient or functional food and may contribute considerably to promote consumer health.