Circulating Tumor Cell Isolation: Efficient Purification and Release of Circulating Tumor Cells by Synergistic Effect of Biomarker and SiO2@Gel-Microbead-Based Size Difference Amplification (Adv. Healthcare Mater. 13/2016)
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- 作者：Qinqin Huang ; Bo Cai ; Bolei Chen ; Lang Rao ; Zhaobo He ; Rongxiang He ; Feng Guo ; Libo Zhao ; Kiran Kumar Kondamareddy ; Wei Liu ; Shishang Guo and Xing-Zhong Zhao
- 刊名：Advanced Healthcare Materials
- 出版年：2016
- 出版时间：July 6, 2016
- 年：2016
- 卷：5
- 期：13
- 页码：1525
- 全文大小：2803K
- ISSN：2192-2659
文摘
Efficient high-purity recovery of viable circulating tumor cells (CTCs) allows the detection and characterization of cancer. On page 1554, W. Liu, S. S. Guo, X.-Z. Zhao, and co-workers describe a microfluidics-based CTC-isolation approach using CTC-specific antibodies conjugated to silica microbeads. Continuous-flow purification of CTCs is realized by laminar-like interfaces. Based on a cell capture and release platform, viable cancer cells can be isolated from CTC blood samples. The low-cost yet effective method is promising for point-of-care pharmacotherapy.