Pyrazolo[1,5-a]Pyrimidine Derivative as Precursor for Some Novel Pyrazolo[1,5-a]Pyrimidines and Tetraheterocyclic Compounds

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• 作者：Nadia Hanafy Metwally ; Magda Ahmed Abdallah and Selima Ali Almabrook
• 刊名：Journal of Heterocyclic Chemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：54
• 期：1
• 页码：347-354
• 全文大小：1123K
• ISSN：1943-5193

文摘

The 2-(cyanomethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carbonitrile reacted with phenyl isothiocyanate to afford the respective thioanilide derivative that is a novel compound that has been unreported hitherto. The latter was used as a precursor to synthesize several novel polyheterocyclic compounds , , , and . Treatment of the enamine derivative of compound with each of hydrazine hydrate and hydroxylamine hydrochloride yielded the tetraheterocyclic compounds and , respectively. The structures of all the newly synthesized compounds were confirmed on basis of their elemental, spectral data, and plausible mechanism has been postulated to account for their formation. X-ray crystallography was carried out as a further evidence for the structure of the isolated product .