Cross-Coupling of Organolithium with Ethers or Aryl Ammonium Salts by C−O or C−N Bond Cleavage
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- 作者：Ze-Kun Yang ; Dong-Yu Wang ; Hiroki Minami ; Hiroyuki Ogawa ; Takashi Ozaki ; Dr. Tatsuo Saito ; Dr. Kazunori Miyamoto ; Dr. Chao Wang and Prof. Dr. Masanobu Uchiyama
- 刊名：Chemistry - A European Journal
- 出版年：2016
- 出版时间：October 24, 2016
- 年：2016
- 卷：22
- 期：44
- 页码：15693-15699
- 全文大小：1544K
- ISSN：1521-3765
文摘
Various aryl-, alkenyl-, and/or alkyllithium species reacted smoothly with aryl and/or benzyl ethers with cleavage of the inert C−O bond to afford cross-coupled products, catalyzed by commercially available [Ni(cod)2] (cod=1,5-cyclooctadiene) catalysts with N-heterocyclic carbene (NHC) ligands. Furthermore, the coupling reaction between the aryllithium compounds and aryl ammonium salts proceeded under mild conditions with C−N bond cleavage in the presence of a [Pd(PPh3)2Cl2] catalyst. These methods enable selective sequential functionalizations of arenes having both C−N and C−O bonds in one pot.