MTHFR c.677C>T is a risk factor for non-syndromic cleft lip with or without cleft palate in Chile

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• 作者：C Ramí ; rez-Chau ; R Blanco ; A Colombo ; R Pardo and J Suazo
• 刊名：Oral Diseases
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：22
• 期：7
• 页码：703-708
• 全文大小：124K
• ISSN：1601-0825

文摘

The functional variant within the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene c.677C>T, producing alterations in folate metabolism, has been associated with the risk of non-syndromic cleft lip with or without cleft palate (NSCL/P). We assessed this association in a Chilean population using a combined analysis of case–control and case–parent trio samples.