Quaternary Ammonium Salt-Promoted Multi-Component Reaction in Water: Access to 3-Alkyl-2, 3-Dihydro-1H-Isoindolin-1-One Derivatives

详细信息    查看全文

• 作者：Fu-Zhong Han ; Bo-Bo Su ; Li-Na Jia ; Peng-Wei Wang and Xiang-Ping Hu
• 刊名：Advanced Synthesis & Catalysis
• 出版年：2017
• 出版时间：January 4, 2017
• 年：2017
• 卷：359
• 期：1
• 页码：146-152
• 全文大小：1185K
• ISSN：1615-4169

文摘

A concise synthesis of alkyl-2,3-dihydro-1H-isoindolin-1-one derivatives from 2-formyl benzoic acid, β-keto acid, and ammonia or primary amine was developed via a quaternary ammonium salt-promoted multi-component sequence of decarboxylative alkylation/lactamization reaction in water, in which the target products were obtained in good to excellent yields.