Bergamotane Sesquiterpenes with Alpha-Glucosidase Inhibitory Activity from the Plant Pathogenic Fungus Penicillium expansum

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• 作者：You-Min Ying ; Cheng-An Fang ; Feng-Qi Yao ; Yuan Yu ; Ying Shen ; Zhuo-Ni Hou ; Zhen Wang ; Wei Zhang ; Wei-Guang Shan and Zha-Jun Zhan
• 刊名：Chemistry & Biodiversity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：14
• 期：1
• 全文大小：183K
• ISSN：1612-1880

文摘

Two new bergamotane sesquiterpene lactones, named expansolides C and D (1 and 2), together with two known compounds expansolides A and B (3 and 4), were isolated from the plant pathogenic fungus Penicillium expansum ACCC37275. The structures of the new compounds were established by detailed analyses of the spectroscopic data, especially 1D-, 2D-NMR, and HR-ESI-MS. In an in vitro bioassay, the epimeric mixture of expansolides C and D (1 and 2) (in a ratio of 2:1 at the temprature of the bioassay) exhibited more potent α-glucosidase inhibitory activity (IC₅₀ =0.50 ± 0.02 mm) as compared with the positive control acarbose (IC₅₀ = 1.90 ± 0.05 mm). To the best of our knowledge, it was the first report on the α-glucosidase inhibitory activity of bergamotane sesquiterpenes.