Copper is a Cofactor of the Formylglycine-Generating Enzyme

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• 作者：Matthias Knop ; Thanh Quy Dang ; Prof. Dr. Gunnar Jeschke and Prof. Dr. Florian P. Seebeck
• 刊名：ChemBioChem
• 出版年：2017
• 出版时间：January 17, 2017
• 年：2017
• 卷：18
• 期：2
• 页码：161-165
• 全文大小：753K
• ISSN：1439-7633

文摘

Formylglycine-generating enzyme (FGE) is an O₂-utilizing oxidase that converts specific cysteine residues of client proteins to formylglycine. We show that Cu^I is an integral cofactor of this enzyme and binds with high affinity (K_D=of 10⁻¹⁷ m) to a pair of active-site cysteines. These findings establish FGE as a novel type of copper enzyme.