Dose-related antihyperglycemic and hypolipidemic effects of two novel thiazolidin-4-ones in a rodent model of metabolic syndrome 两种新型的噻唑烷-4-酮类药物在代谢综合征啮齿类动物模型中具有剂量相关的降血糖与降血脂作用

详细信息    查看全文

• 作者：Sarine Sebastian Karot ; Vasantharaju Gowdra Surenahalli ; Anoop Kishore ; Jayesh Mudgal ; Krishnadas Nandakumar ; Magith Thambi Chirayil ; Geetha Mathew and Gopalan Kutty Nampurath
• 刊名：Journal of Diabetes
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：8
• 期：5
• 页码：629-639
• 全文大小：493K
• ISSN：1753-0407

文摘

The replacement of the thiazolidinedione moiety with a thiazolidinone may yield antidiabetic compounds with similar pleiotropic effects. Hence, the aim of the present study was to explore the dose-related antihyperglycemic and hypolipidemic effects of two synthesized novel thiazolidin-4-one derivatives, one with a nicotinamide and the other with a p-chlorophenoxyacetamide substitution at the N3 position of the thiazolidinone ring (NAT1 and PAT1, respectively), in a rodent model of metabolic syndrome (MetS).