In this paper, the authors first presented the tectonic setting of southeastern Tibet and surrounding areas firstly and then analyzed the characteristics of seismic activity in this region by investigating activities of strong earthquakes and Load/Unload Response Ratio (LURR) time series of segments of the boundaries among active tectonic blocks. In view of the historical seismicity, the authors found a certain kinematical association between the Andaman arc and the eastern Himalayan system, and the current dynamic environment is strong seismicly in the Andaman arc and seismicly quiescent in eastern Himalayan system. From the image of seismic activities, earthquakes with magnitude larger than or equal to 6.0 since 1980 have formed a circular seismic gap in southeastern Tibet and surrounding areas, whose spatial distribution is similar to that during the 10 years before the 1950 Medog-Zayu M8.6 earthquake. In terms of the LURR time series for segments of the active tectonic boundaries in the region, the eastern segment of Himalayan boundary is in the high stress state, followed by the Lancang River and Sanjiang tectonic boundaries.