The mid-western Tabei uplift in Tarim Basin is in good prospects for petroleum exploration, but has complex petroleum geological features. The regional geologic data analysis indicates that the mid-section of south Tianshan oceanic basin was formed in Late Ordovician-Early Silurian, and Tabei slope was good geological background for oil-gas enrichment in this area. It is indicated from Yingshan Formation source rock samples of Ha-6 Well that the organic carbon content in its dolomitic limestone with thickness of 130 m is higher than 0.5%, showing the Lower Ordovician in this area belongs to commercial source rocks, which could broaden the depth and domain of exploration here. Study shows that the mid-western Tabei uplift is of conditions of complex paleo-karst system, along the unconformity and adjacent pinch-out are favorable areas for large-scale paleo-karst oil-gas reservoirs.