In order to get an accurate understanding of the formation and distribution of hydrocarbon reservoirs, on the premise of reconstructing the strata denudation thickness in Liaodong bay area of late-stage of Paleogene based on analysis of sonic time difference and stratigraphy trend thickness method, the hydrocarbon accumulation history in Liaoxi low uplift and Liaozhong sag has been revealed based on hydrocarbon generating history, homogenization temperatures of fluid inclusions, geothermal history, burial history, oil characteristics, temperature and pressure of reservoir as well.The research indicates that the denudation ranges from 150 to 450 m in range, and the key hydrocarbon charging time of the oil and gas in Liaoxi low uplift and Liaozhong sag are after 12 Ma, both are late-stage petroleum accumulation.