The principle and structure method of block rigid movement and least squares collocation model were introduced, and the movement tendency and interior deformation of Bayanhar Block in the Qinghai-Tibetan Plateau were discussed. Based on least squares collocation model, covariance matrixes between collocation points and measurement points were established. The results indicated that the crustal deformation of Bayanhar Block was influenced by subduction of Indian Plate and eastward movement of the Qinghai-Tibetan Plateau, the Euler vector of block rotation was ((0.45°±0.14°)/Ma, (-17.5°±5.93°)N), (-77.91°±12.9°)E); velocity gradually decreased northward and increased eastward in the eastern of Bayanhar Block.