The background of permafrost degradation in the Qinghai-Tibetan Plateau and its engineering impact in the region were introduced. Based on the results of geo-hazard investigations and ground-temperature monitoring of the roadbeds along the Qinghai-Tibetan Railway in the permafrost regions, the development of ground temperature, thermal stability and secondary freezing-thawing hazards since 2002 were analyzed. The results showed that the roadbeds in the permafrost regions are stable in the whole since it was open to traffic in 2006. The train speed reaches 100 km/h, which achieves the design requirements. In-situ monitored results indicated that thermal stability of the roadbed constructed with a principle of "active cooling" method is much better than that of traditional roadbed.