The Changandeersi molybdenum deposit is a concealed large-size molybdenum deposit newly discovered in western Inner Mongolia. It is a porphyry molybdenum deposit characterized by disseminated, spot and veinlet mineralizations hosted in medium-fine grained monzonitic granite. Re-Os isotopic dating of seven samples from various ore bodies of the ore deposit yields model ages between (240.3±3.9) Ma and (244.2±3.5) Ma, and isochron age of (243.0±2.2) Ma, with initial 187Os being (-0.3±2.4) and MSWD being 0.78, indicating that molybdenum mineralization took place in Triassic and had a association with tectonomagmatic orogenic process in Indosinian period. The characteristics of granites related to mineralization and molybdenum deposits in this ore belt and the prospecting criteria are summed up in this paper.