Based on the analysis of fluid inclusions (including the laser Raman spectroscopy), hydrogen and oxygen isotope in the quartz grains formed in different metallogenic stages, ore-forming physical-chemical condition and ore genesis of the Taoxikeng tungsten and tin deposit in the southern Jiangxi Province were summarized. The results indicates that the ore-forming fluid was derived from the deep magmatic water. According to data mentioned above and from other research in this area, it can be concluded that the Taoxikeng deposit belongs to the magmatic hydrothermal tungsten and tin deposit associated with the S-type granite.