The minerals in Guizhou Province that have relation with the E’ mei mantle plume in different evolution stages were divided into three kinds:one is crust and mantle interaction stage, the Carboniferous sedimentary bauxite formed in the Zunyi broken arch because the crustal uplift;second is the eruption and degrade stage, geothermal sedimentary manganese, ferro-manganese, manganese bearing siderite, basalt cooper, volcanosedimentary pyrites that has direct relation with basalt formed;third maybe is eruption and degrade stage of E’ mei mantle plume, as the interaction of crust and mantle, the raise of mantle heat flow induced the anatexis of the crust, the middle-low temperature geothermal deposit formed by different geologic responses, and some is the correlative middle-low temperature geothermal deposit which activated by the remaining solidified mantle in the late eruption and degrade stage.