Based on the analysis of relevant literature, the paper defines the concept of urban agglomeration tourism destination. Besides, the paper conducts a quantitative research on the tourism network structure of the Pearl River Delta. The results show that the degree of the closeness, reach centrality and intermediate of Guangzhou is higher than those of the others, Guangzhou is also the distribution center of the domestic tourists in the Pearl River Delta, so Guangzhou is the tourism centre of the Pearl River Delta. Bordering Hong Kong and Macao, Shenzhen and Zhuhai are important tourism destinations of the Pearl River Delta, and also the distribution center of Hong Kong and Macao tourists reaching the Mainland.