The Fule Pb-Zn deposit is located in the southeast part of Sichuan-Yunnan-Guizhou lead-zinc polymetallic district. Based on systematic studies on major elements, trace elements, and electron probe X-ray microanalysis, following achievements have been obtained. The sphalerite trace elements are Cd(16 183×10-6); Cu(1 514×10-6); Ni(414×10-6); As(215×10-6); Se(163×10-6); Ge(135×10-6); Ga(86×10-6);Sb(35×10-6); Ag(16×10-6), and Cr, Co, Mn, Ba, Ti, Sr, Mo, average content of 1×10-6~10×10-6. There is correlation among Cd and Cu, Ag, Sb, As, Ni.The variation of colors of sphalerite is caused by these trace elements, Ni induces purple, Cu red and Ga yellow.