Why we should not routinely apply irreversible electroporation as an alternative curative treatment modality for localized prostate cancer at this stage

详细信息    查看全文

• 作者：J. J. Wendler ; R. Ganzer ; B. Hadaschik ; A. Blana ; T. Henkel…
• 关键词：Focal therapy ; Ablation ; Irreversible electroporation ; Prostate ; Localized prostate cancer ; Definitive treatment
• 刊名：World Journal of Urology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：35
• 期：1
• 页码：11-20
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Urology; Nephrology; Oncology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1433-8726
• 卷排序：35

文摘

Irreversible electroporation (IRE), a new tissue ablation procedure available since 2007, could meet the requirements for ideal focal therapy of prostate cancer with its postulated features, especially the absence of a thermal ablation effect. Thus far, there is not enough evidence of its effectiveness or adverse effects to justify its use as a definitive treatment option for localized prostate cancer. Moreover, neither optimal nor individual treatment parameters nor uniform endpoints have been defined thus far. No advantages over established treatment procedures have as yet been demonstrated. Nevertheless, IRE is now being increasingly applied for primary prostate cancer therapy outside clinical trials, not least through active advertising in the lay press. This review reflects the previous relevant literature on IRE of the prostate or prostate cancer and shows why we should not adopt IRE as a routine treatment modality at this stage.